Paper information
- Authors
-
- Daniel Grint,
- Kevin Wing,
- Elizabeth Williamson,
- Helen McDonald,
- Krishnan Bhaskaran,
- Dave Evans,
- Stephen Evans,
- Alex Walker,
- George Hickman,
- Emily Nightingale,
- Anna Schultze,
- Christopher Rentsch,
- Chris Bates,
- Jonathan Cockburn,
- Helen Curtis,
- Caroline Morton,
- Seb Bacon,
- Simon Davy,
- Angel Wong,
- Amir Mehrkar,
- Laurie Tomlinson,
- Ian Douglas,
- Rohini Mathur,
- Paula Blomquist,
- Brian MacKenna,
- Peter Ingelsby,
- Richard Croker,
- John Parry,
- Frank Hester,
- Sam Harper,
- Nick DeVito,
- Will Hulme,
- John Tazare,
- Ben Goldacre,
- Liam Smeeth,
- Rosalind Eggo
- Citation
- Grint Daniel J, Wing Kevin, Williamson Elizabeth, McDonald Helen I, Bhaskaran Krishnan, Evans David, Evans Stephen JW, Walker Alex J, Hickman George, Nightingale Emily, Schultze Anna, Rentsch Christopher T, Bates Chris, Cockburn Jonathan, Curtis Helen J, Morton Caroline E, Bacon Sebastian, Davy Simon, Wong Angel YS, Mehrkar Amir, Tomlinson Laurie, Douglas Ian J, Mathur Rohini, Blomquist Paula, MacKenna Brian, Ingelsby Peter, Croker Richard, Parry John, Hester Frank, Harper Sam, DeVito Nicholas J, Hulme Will, Tazare John, Goldacre Ben, Smeeth Liam, Eggo Rosalind M. Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February. Euro Surveill. 2021;26(11):pii=2100256. https://doi.org/10.2807/1560-7917.ES.2021.26.11.2100256
- Categories
Abstract
The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34–2.09; p < 0.0001). Absolute risk of death by 28 days increased with age and comorbidities. This VOC has potential to spread faster with higher mortality than the pandemic to date.